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Human polyomaviruses and other human viruses in neuroendocrine tumors

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Background: While the association of the Merkel cell polyomavirus (MCV) with the neuroendocrine Merkel cell carcinomas (MCC) has been shown recently, it is unknown whether other human polyomaviruses (HPyV) may be associated with neuroendocrine tumours (NETs) of distinct entities.Methods: Using novel...

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Main Authors: Schmitt, Markus (Author) , Höfler, Daniela (Author) , Koleganova, Nadezda (Author) , Pawlita, Michael (Author)
Format: Article (Journal)
Language:English
Published: [1 July 2011]
In: Cancer epidemiology, biomarkers & prevention
Year: 2011, Volume: 20, Issue: 7, Pages: 1558-1561
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-11-0424
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1055-9965.EPI-11-0424
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Author Notes:Markus Schmitt, Daniela Höfler, Nadezda Koleganova, and Michael Pawlita
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Summary:Background: While the association of the Merkel cell polyomavirus (MCV) with the neuroendocrine Merkel cell carcinomas (MCC) has been shown recently, it is unknown whether other human polyomaviruses (HPyV) may be associated with neuroendocrine tumours (NETs) of distinct entities.Methods: Using novel, highly sensitive polyomavirus genotyping assays, we evaluated the prevalence of eight distinct HPyVs in a selection of 51 NETs from different entities. In addition, we analyzed these NETs for the presence of DNA from 12 adeno-associated virus (AAV) genotypes, adeno virus-5, 27 mucosal human papillomavirus (HPV) genotypes, hepatitis B (HBV), 8 human herpes viruses (HHV), and xenotropic murine leukemia virus-related virus (XMRV).Results: 43 of the 50 (86%) NETs were positive for the DNA integrity control. Of these, 2 of 3 MCCs (67%) were positive for MCV. NETs from other entities, however, were negative for all HPyVs. Only a small subset of lung and appendix NETs were positive for EBV, HHV-6, and -7.Conclusion: While the association of MCV with MCC was confirmed, other human viruses could not be identified as potentially causative agents of other NETs.Impact: Our findings suggest that the human viruses tested for in this study do not play a comparable role in NETs like the polyomavirus MCV in MCC. Cancer Epidemiol Biomarkers Prev; 20(7); 1558-61. ©2011 AACR.
Item Description:Gesehen am 12.10.2022
Physical Description:Online Resource
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-11-0424

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