Calcium signaling in cognition and aging-dependent cognitive decline
Calcium-dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging-dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity-dependent act...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 June 2011
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| In: |
Biofactors
Year: 2011, Volume: 37, Issue: 3, Pages: 168-174 |
| ISSN: | 1872-8081 |
| DOI: | 10.1002/biof.148 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/biof.148 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.148 
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| Author Notes: | Ana MM Oliveira and Hilmar Bading |
| Summary: | Calcium-dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging-dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity-dependent activation of transcription responsible for the synthesis of molecules underlying the long-term changes of neuronal function. Effectors of calcium signaling with a primordial role in transcription regulation are calcium signal-regulated transcription factors. In this review, we summarize the current knowledge of the contribution of key calcium signal-regulated transcription factors, namely CREB, NFAT, and DREAM, to memory formation. We further describe evidence for dysregulation of the activity of these factors during aging. |
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| Item Description: | Gesehen am 12.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8081 |
| DOI: | 10.1002/biof.148 |