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Enzyme-degradable 3D multi-material microstructures

There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety tha...

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Bibliographic Details
Main Authors: Gräfe, David (Author) , Gernhardt, Marvin (Author) , Ren, Jiongyu (Author) , Blasco, Eva (Author) , Wegener, Martin (Author) , Woodruff, Maria Ann (Author) , Barner-Kowollik, Christopher (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Advanced functional materials
Year: 2021, Volume: 31, Issue: 3, Pages: 1-8
ISSN:1616-3028
DOI:10.1002/adfm.202006998
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adfm.202006998
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202006998
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Author Notes:David Gräfe, Marvin Gernhardt, Jiongyu Ren, Eva Blasco, Martin Wegener, Maria Ann Woodruff, and Christopher Barner-Kowollik
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Summary:There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety that is recognized and cleaved by the enzyme chymotrypsin. Macroscopic films as well as microstructures are fabricated via the use of direct laser writing. Multi-material boxing ring microstructures are generated and selectively degraded by the enzyme. Cell biocompatibility studies indicate that cells are able to attach and proliferate over one week on the material. A photoresist that is biocompatible and can be entirely removed by a biocompatible stimulus such as an enzyme can potentially be used as an easily removed tissue engineering scaffold and is especially promising for basic cell biology research.
Item Description:Published online: October 7, 2020
Gesehen am 12.10.2022
Physical Description:Online Resource
ISSN:1616-3028
DOI:10.1002/adfm.202006998

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