Enzyme-degradable 3D multi-material microstructures
There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety tha...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
Advanced functional materials
Year: 2021, Jahrgang: 31, Heft: 3, Pages: 1-8 |
| ISSN: | 1616-3028 |
| DOI: | 10.1002/adfm.202006998 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adfm.202006998 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202006998 
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| Verfasserangaben: | David Gräfe, Marvin Gernhardt, Jiongyu Ren, Eva Blasco, Martin Wegener, Maria Ann Woodruff, and Christopher Barner-Kowollik |
| Zusammenfassung: | There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety that is recognized and cleaved by the enzyme chymotrypsin. Macroscopic films as well as microstructures are fabricated via the use of direct laser writing. Multi-material boxing ring microstructures are generated and selectively degraded by the enzyme. Cell biocompatibility studies indicate that cells are able to attach and proliferate over one week on the material. A photoresist that is biocompatible and can be entirely removed by a biocompatible stimulus such as an enzyme can potentially be used as an easily removed tissue engineering scaffold and is especially promising for basic cell biology research. |
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| Beschreibung: | Published online: October 7, 2020 Gesehen am 12.10.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1616-3028 |
| DOI: | 10.1002/adfm.202006998 |