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Do instrumental activities of daily living predict Dementia at 1- and 2-year follow-up?: findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's disease study

Objectives To investigate whether problems in instrumental activities of daily living (IADL) can add to conventionally used clinical measurements in helping to predict a diagnosis of dementia at 1- and 2-year follow-up. Design Multicenter prospective cohort study. Setting Memory clinics in Europe. P...

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Main Authors: Sikkes, Sietske (Author) , Visser, Pieter Jelle (Author) , Knol, Dirk L. (Author) , de Lange-de Klerk, Elly S. M. (Author) , Tsolaki, Magda (Author) , Frisoni, Giovani B. (Author) , Nobili, Flavio (Author) , Spiru, Luiza (Author) , Rigaud, Anne Sophie (Author) , Frölich, Lutz (Author) , Rikkert, Marcel Olde (Author) , Soininen, Hilkka (Author) , Touchon, Jacques (Author) , Wilcock, Gordon (Author) , Boada, Mercè (Author) , Hampel, Harald (Author) , Bullock, Roger (Author) , Vellas, Bruno (Author) , Pijnenburg, Yolande A.L. (Author) , Scheltens, Philip (Author) , Verhey, Frans R. (Author) , Uitdehaag, Bernard M.J. (Author)
Format: Article (Journal)
Language:English
Published: 20 December 2011
In: Journal of the American Geriatrics Society
Year: 2011, Volume: 59, Issue: 12, Pages: 2273-2281
ISSN:1532-5415
DOI:10.1111/j.1532-5415.2011.03732.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1532-5415.2011.03732.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-5415.2011.03732.x
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Author Notes:Sietske A.M. Sikkes, Pieter Jelle Visser, Dirk L. Knol, Elly S.M. de Lange-de Klerk, Magda Tsolaki, Giovani B. Frisoni, Flavio Nobili, Luiza Spiru, Anne Sophie Rigaud, Lutz Frölich, Marcel Olde Rikkert, Hilkka Soininen, Jacques Touchon, Gordon Wilcock, Mercè Boada, Harald Hampel, Roger Bullock, Bruno Vellas, Yolande A.L. Pijnenburg, Philip Scheltens, Frans R. Verhey, and Bernard M.J. Uitdehaag
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Summary:Objectives To investigate whether problems in instrumental activities of daily living (IADL) can add to conventionally used clinical measurements in helping to predict a diagnosis of dementia at 1- and 2-year follow-up. Design Multicenter prospective cohort study. Setting Memory clinics in Europe. Participants Individuals aged 55 and older without dementia. Measurements IADLs were measured using pooled activities from five informant-based questionnaires. Structural equation modeling (SEM) was used to investigate the relation between IADLs and dementia. Age, sex, education, depression, and cognitive measures (Mini-Mental State Examination and verbal memory) were included in the model. Results Five hundred thirty-one participants had baseline and 1-year follow-up assessments; 69 (13.0%) of these had developed dementia at 1-year follow-up. At 2-year follow-up, 481 participants were seen, of whom 100 (20.8%) had developed dementia. Participants with IADL disabilities at baseline had a higher conversion rate (24.4%) than participants without IADL disabilities (16.7%) (chi-square = 4.28, degrees of freedom = 1, P = .04). SEM showed that IADL disability could help predict dementia in addition to the measured variables at 1-year follow-up (odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.51-3.13) and 2-year follow-up (OR = 2.11, 95% CI = 1.33-3.33). Conclusion IADL disability is a useful addition to the diagnostic process in a memory clinic setting, indicating who is at higher risk of developing dementia at 1- and 2-year follow-up.
Item Description:Gesehen am 13.10.2022
Physical Description:Online Resource
ISSN:1532-5415
DOI:10.1111/j.1532-5415.2011.03732.x

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