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Protocol of the TREASURE study: Thoracic RadiothErapy with Atezolizumab in Small cell lUng canceR Extensive disease$da randomized, open-label, multicenter phase II trial

Recently, the combination of the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab with first-line chemotherapy has demonstrated to improve outcome for patients with advanced small cell lung cancer (SCLC), leading to approval of this regimen. At the same time, accumulating (pre-)clinical data...

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Main Authors: Bozorgmehr, Farastuk (Author) , Christopoulos, Petros (Author) , Chung, Inn (Author) , Cvetkovic, Jelena (Author) , Feißt, Manuel (Author) , Krisam, Johannes (Author) , Schneider, Marc (Author) , Heußel, Claus Peter (Author) , Kreuter, Michael (Author) , Müller, Daniel W. (Author) , Thomas, Michael (Author) , Rieken, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 24 September 2022
In: BMC cancer
Year: 2022, Volume: 22, Pages: 1-9
ISSN:1471-2407
DOI:10.1186/s12885-022-10074-9
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12885-022-10074-9
Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10074-9
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Author Notes:Farastuk Bozorgmehr, Petros Christopoulos, Inn Chung, Jelena Cvetkovic, Manuel Feißt, Johannes Krisam, Marc A. Schneider, Claus Peter Heußel, Michael Kreuter, Daniel W. Müller, Michael Thomas and Stefan Rieken
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Summary:Recently, the combination of the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab with first-line chemotherapy has demonstrated to improve outcome for patients with advanced small cell lung cancer (SCLC), leading to approval of this regimen. At the same time, accumulating (pre-)clinical data suggest synergisms of radiotherapy and immunotherapy via the radiation-mediated induction of anti-tumor immunogenicity. Combining the recent findings, the TREASURE trial aims at further enhancing response to upfront chemo-immunotherapy by the addition of thoracic radiotherapy (TRT).
Item Description:Gesehen am 18.10.2022
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-022-10074-9

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