Molecular imaging of proliferation and glucose utilization: utility for monitoring response and prognosis after neoadjuvant therapy in locally advanced gastric cancer

Metabolic imaging of gastric cancer is limited due to the 30% of primary tumors that are not 18F-fluorodeoxyglucose (FDG) avid. In contrast, the proliferation marker 18F-fluorothymidine (FLT) has been shown to visualize also non-FDG-avid gastric tumors. In this study we tested whether FLT-positron e...

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Main Authors: Ott, Katja (Author) , Herrmann, Ken (Author) , Schuster, Tibor (Author) , Langer, Rupert (Author) , Becker, Karen (Author) , Wieder, Hinrich A. (Author) , Wester, Hans-Jürgen (Author) , Siewert, Jörg R. (Author) , Meyer zum Büschenfelde, Christian Olaf (Author) , Buck, Andreas K. (Author) , Wilhelm, Dirk (Author) , Ebert, Matthias (Author) , Peschel, Christian (Author) , Schwaiger, Markus (Author) , Lordick, Florian (Author) , Krause, Bernd Joachim (Author)
Format: Article (Journal)
Language:English
Published: 03 May 2011
In: Annals of surgical oncology
Year: 2011, Volume: 18, Issue: 12, Pages: 3316-3323
ISSN:1534-4681
DOI:10.1245/s10434-011-1743-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1245/s10434-011-1743-y
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Author Notes:Katja Ott, MD, Ken Herrmann, MD, Tibor Schuster, PhD, Rupert Langer, MD, Karen Becker, MD, Hinrich A. Wieder, MD, Hans-Jürgen Wester, PhD, Jörg-Rüdiger Siewert, MD, Christian Meyer zum Büschenfelde, MD, Andreas K. Buck, MD, Dirk Wilhelm, MD, Matthias P.A. Ebert, MD, Christian Peschel, MD, Markus Schwaiger, MD, Florian Lordick, MD, and Bernd Joachim Krause, MD
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Summary:Metabolic imaging of gastric cancer is limited due to the 30% of primary tumors that are not 18F-fluorodeoxyglucose (FDG) avid. In contrast, the proliferation marker 18F-fluorothymidine (FLT) has been shown to visualize also non-FDG-avid gastric tumors. In this study we tested whether FLT-positron emission tomography (PET) can improve the predictive potential of molecular imaging for assessing response to neoadjuvant therapy in gastric cancer compared with FDG-PET.
Item Description:Gesehen am 19.10.2022
Physical Description:Online Resource
ISSN:1534-4681
DOI:10.1245/s10434-011-1743-y