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Performance status is the most powerful risk factor for early death among patients with advanced soft tissue sarcoma: the European Organisation for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (STBSG) and French Sarcoma Group (FSG) study

BACKGROUND: We investigated prognostic factors (PFs) for 90-day mortality in a large cohort of advanced/metastatic soft tissue sarcoma (STS) patients treated with first-line chemotherapy. - METHODS: The PFs were identified by both logistic regression analysis and probability tree analysis in patient...

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Main Authors: Penel, Nicolas (Author) , Glabbeke, M. V. (Author) , Mathoulin-Pelissier, S. (Author) , Judson, I. (Author) , Sleijfer, S. (Author) , Bui, B. (Author) , Schoffski, P. (Author) , Ouali, M. (Author) , Marreaud, S. (Author) , Brouste, V. (Author) , Duhamel, A. (Author) , Hohenberger, Peter (Author) , Blay, J.-Y. (Author)
Format: Article (Journal)
Language:English
Published: 19 April 2011
In: British journal of cancer
Year: 2011, Volume: 104, Issue: 10, Pages: 1544-1550
ISSN:1532-1827
DOI:10.1038/bjc.2011.136
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2011.136
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Author Notes:N. Penel, M.V. Glabbeke, S. Mathoulin-Pelissier, I. Judson, S. Sleijfer, B. Bui, P. Schoffski, M. Ouali, S. Marreaud, V. Brouste, A. Duhamel, P. Hohenberger and J.-Y. Blay
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Summary:BACKGROUND: We investigated prognostic factors (PFs) for 90-day mortality in a large cohort of advanced/metastatic soft tissue sarcoma (STS) patients treated with first-line chemotherapy. - METHODS: The PFs were identified by both logistic regression analysis and probability tree analysis in patients captured in the Soft Tissue and Bone Sarcoma Group (STBSG) database (3002 patients). Scores derived from the logistic regression analysis and algorithms derived from probability tree analysis were subsequently validated in an independent study cohort from the French Sarcoma Group (FSG) database (404 patients). - RESULTS: The 90-day mortality rate was 8.6 and 4.5% in both cohorts. The logistic regression analysis retained performance status (PS; odds ratio (OR)=3.83 if PS=1, OR=12.00 if PS ≥2), presence of liver metastasis (OR=2.37) and rare site metastasis (OR=2.00) as PFs for early death. The CHAID analysis retained PS as a major discriminator followed by histological grade (only for patients with PS ≥2). In both models, PS was the most powerful PF for 90-day mortality. - CONCLUSION: Performance status has to be taken into account in the design of further clinical trials and is one of the most important parameters to guide patient management. For those patients with poor PS, expected benefits from therapy should be weighed up carefully against the anticipated toxicities.
Item Description:Gesehen am 19.10.2022
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/bjc.2011.136

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