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Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of t...

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Main Authors: Slof-Op 't Landt, Rita (Author) , Meulenbelt, I. (Author) , Bartels, M. (Author) , Suchiman, E. (Author) , Middeldorp, C. M. (Author) , Houwing-Duistermaat, J. J. (Author) , van Trier, J. (Author) , Onkenhout, E. J. (Author) , Vink, J. M. (Author) , van Beijsterveldt, C. E. M. (Author) , Brandys, M. K. (Author) , Sanders, N. (Author) , Zipfel, Stephan (Author) , Herzog, Wolfgang (Author) , Herpertz-Dahlmann, Beate (Author) , Klampfl, K. (Author) , Fleischhaker, C. (Author) , Zeeck, A. (Author) , de Zwaan, M. (Author) , Herpertz, Sabine (Author) , Ehrlich, S. (Author) , van Elburg, A. A. (Author) , Adan, R. a. H. (Author) , Scherag, S. (Author) , Hinney, A. (Author) , Hebebrand, J. (Author) , Boomsma, D. I. (Author) , van Furth, E. F. (Author) , Slagboom, P. E. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Genes, brain and behavior
Year: 2011, Volume: 10, Issue: 2, Pages: 236-243
ISSN:1601-183X
DOI:10.1111/j.1601-183X.2010.00660.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1601-183X.2010.00660.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1601-183X.2010.00660.x
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Author Notes:M.C.T. Slof-Op ‘t Landt, I. Meulenbelt, M. Bartels, E. Suchiman, C.M. Middeldorp, J.J. Houwing-Duistermaat, J. van Trier, E.J. Onkenhout, J.M. Vink, C.E.M. van Beijsterveldt, M.K. Brandys, N. Sanders, S. Zipfel, W. Herzog, B. Herpertz-Dahlmann, K. Klampfl, C. Fleischhaker, A. Zeeck, M. de Zwaan, S. Herpertz, S. Ehrlich, A.A. van Elburg, R.a.H. Adan, S. Scherag, A. Hinney, J. Hebebrand, D.I. Boomsma, E.F. van Furth and P.E. Slagboom
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Summary:Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values < 0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P < 0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group.
Item Description:Erstmals veröffentlicht am 14. Oktober 2010
Gesehen am 20.10.2022
Physical Description:Online Resource
ISSN:1601-183X
DOI:10.1111/j.1601-183X.2010.00660.x

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