Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia
Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age (p=0.01 and p=0.03, respectively). Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precu...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 May 2011
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| In: |
Leukemia research
Year: 2011, Volume: 35, Issue: 10, Pages: 1345-1349 |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2011.04.015 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.leukres.2011.04.015 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0145212611002049 
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| Author Notes: | Seisho Takeuchi, Masahide Matsushita, Martin Zimmermann, Takayuki Ikezoe, Naoki Komatsu, Taku Seriu, Martin Schrappe, Claus R. Bartram, H. Phillip Koeffler |
| Summary: | Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age (p=0.01 and p=0.03, respectively). Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL (p=0.02 and p=0.01, respectively). In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL (p=0.01). Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk (p=0.004 and p=0.03, respectively). These results suggest that methylation status is associated with clinicopathological features in childhood ALL. |
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| Item Description: | Gesehen am 20.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2011.04.015 |