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Common breast cancer susceptibility loci are associated with triple-negative breast cancer

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Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies displ...

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Main Authors: Stevens, Kristen N. (Author) , Sinn, Peter (Author) , Försti, Asta (Author) , Hamann, Ute (Author) , Chang-Claude, Jenny (Author)
Format: Article (Journal)
Language:English
Published: October 1, 2011
In: Cancer research
Year: 2011, Volume: 71, Issue: 19, Pages: 6240-6249
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-11-1266
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-11-1266
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Author Notes:Kristen N. Stevens, Celine M. Vachon, Adam M. Lee, Susan Slager, Timothy Lesnick, Curtis Olswold, Peter A. Fasching, Penelope Miron, Diana Eccles, Jane E. Carpenter, Andrew K. Godwin, Christine Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K. Schmidt, Angela Cox, Simon S. Cross, Elinor Sawyer, Arndt Hartmann, Matthias W. Beckmann, Rüdiger Schulz-Wendtland, Arif B. Ekici, William J. Tapper, Susan M. Gerty, Lorraine Durcan, Nikki Graham, Rebecca Hein, Stephan Nickels, Dieter Flesch-Janys, Judith Heinz, Hans-Peter Sinn, Irene Konstantopoulou, Florentia Fostira, Dimitrios Pectasides, Athanasios M. Dimopoulos, George Fountzilas, Christine L. Clarke, Rosemary Balleine, Janet E. Olson, Zachary Fredericksen, Robert B. Diasio, Harsh Pathak, Eric Ross, JoEllen Weaver, Thomas Rüdiger, Asta Försti, Thomas Dünnebier, Foluso Ademuyiwa, Swati Kulkarni, Katri Pylkäs, Arja Jukkola-Vuorinen, Yon-Dschun Ko, Erik Van Limbergen, Hilde Janssen, Julian Peto, Olivia Fletcher, Graham G. Giles, Laura Baglietto, Senno Verhoef, Ian Tomlinson, Veli-Matti Kosma, Jonathan Beesley, Dario Greco, Carl Blomqvist, Astrid Irwanto, Jianjun Liu, Fiona M. Blows, Sarah-Jane Dawson, Sara Margolin, Arto Mannermaa, Nicholas G. Martin, Grant W. Montgomery, Diether Lambrechts, Isabel dos Santos Silva, Gianluca Severi, Ute Hamann, Paul Pharoah, Douglas F. Easton, Jenny Chang-Claude, Drakoulis Yannoukakos, Heli Nevanlinna, Xianshu Wang, Fergus J. Couch
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Summary:Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.
Item Description:Gesehen am 21.10.2022
Physical Description:Online Resource
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-11-1266

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