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Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Objectives To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM). - Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-report...

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Hauptverfasser: Yeoh, Su-Ann (Verfasst von) , Gianfrancesco, Milena (Verfasst von) , Lawson-Tovey, Saskia (Verfasst von) , Hyrich, Kimme L. (Verfasst von) , Strangfeld, Anja (Verfasst von) , Gossec, Laure (Verfasst von) , Carmona, Loreto (Verfasst von) , Mateus, Elsa F. (Verfasst von) , Schäfer, Martin (Verfasst von) , Richez, Christophe (Verfasst von) , Hachulla, Eric (Verfasst von) , Holmqvist, Marie (Verfasst von) , Scirè, Carlo Alberto (Verfasst von) , Lorenz, Hanns-Martin (Verfasst von) , Voll, Reinhard (Verfasst von) , Hasseli, Rebecca (Verfasst von) , Jayatilleke, Arundathi (Verfasst von) , Hsu, Tiffany Y.-T. (Verfasst von) , D’Silva, Kristin M. (Verfasst von) , Pimentel-Quiroz, Victor R. (Verfasst von) , Mercado, Monica Vasquez del (Verfasst von) , Shinjo, Samuel Katsuyuki (Verfasst von) , Neto, Edgard Torres dos Reis (Verfasst von) , Junior, Laurindo Ferreira da Rocha (Verfasst von) , Montandon, Ana Carolina de Oliveira e Silva (Verfasst von) , Pons-Estel, Guillermo J. (Verfasst von) , Ornella, Sofía (Verfasst von) , Exeni, Maria Eugenia D'Angelo (Verfasst von) , Velozo, Edson (Verfasst von) , Jordan, Paula (Verfasst von) , Sirotich, Emily (Verfasst von) , Hausmann, Jonathan S. (Verfasst von) , Liew, Jean W. (Verfasst von) , Jacobsohn, Lindsay (Verfasst von) , Gore-Massy, Monique (Verfasst von) , Sufka, Paul (Verfasst von) , Grainger, Rebecca (Verfasst von) , Bhana, Suleman (Verfasst von) , Wallace, Zachary (Verfasst von) , Robinson, Philip C. (Verfasst von) , Yazdany, Jinoos (Verfasst von) , Machado, Pedro M. (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 September 2022
In: RMD Open
Year: 2022, Jahrgang: 8, Heft: 2, Pages: 1-8
ISSN:2056-5933
DOI:10.1136/rmdopen-2022-002508
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/rmdopen-2022-002508
Verlag, lizenzpflichtig, Volltext: https://rmdopen.bmj.com/content/8/2/e002508
Volltext
Verfasserangaben:Su-Ann Yeoh, Milena Gianfrancesco, Saskia Lawson-Tovey, Kimme L. Hyrich, Anja Strangfeld, Laure Gossec, Loreto Carmona, Elsa F. Mateus, Martin Schäfer, Christophe Richez, Eric Hachulla, Marie Holmqvist, Carlo Alberto Scirè, Hanns-Martin Lorenz, Reinhard E. Voll, Rebecca Hasseli, Arundathi Jayatilleke, Tiffany Y.-T. Hsu, Kristin M. D’Silva, Victor R. Pimentel-Quiroz, Monica Vasquez del Mercado, Samuel Katsuyuki Shinjo, Edgard Torres dos Reis Neto, Laurindo Ferreira da Rocha Junior, Ana Carolina de Oliveira e Silva Montandon, Guillermo J. Pons-Estel, Sofía Ornella, Maria Eugenia D'Angelo Exeni, Edson Velozo, Paula Jordan, Emily Sirotich, Jonathan S. Hausmann, Jean W. Liew, Lindsay Jacobsohn, Monique Gore-Massy, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado, on behalf of the COVID-19 Global Rheumatology Alliance
Beschreibung
Zusammenfassung:Objectives To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM). - Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death. - Results Of 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65-1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51-0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively). - Conclusions This is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.
Beschreibung:Gesehen am 24.10.2022
Beschreibung:Online Resource
ISSN:2056-5933
DOI:10.1136/rmdopen-2022-002508

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