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E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells

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Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metasta...

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Main Authors: Straub, Beate Katharina (Author) , Rickelt, Steffen (Author) , Zimbelmann, Ralf (Author) , Grund, Christine (Author) , Kuhn, Caecilia (Author) , Iken, Marcus (Author) , Ott, Michael (Author) , Schirmacher, Peter (Author) , Franke, Werner (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: The journal of cell biology
Year: 2011, Volume: 195, Issue: 5, Pages: 873-887
ISSN:1540-8140
DOI:10.1083/jcb.201106023
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1083/jcb.201106023
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Author Notes:Beate K. Straub, Steffen Rickelt, Ralf Zimbelmann, Christine Grund, Caecilia Kuhn, Marcus Iken, Michael Ott, Peter Schirmacher, and Werner W. Franke
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Summary:Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this “cadherin switch” hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.
Item Description:Gesehen am 24.10.2022
Physical Description:Online Resource
ISSN:1540-8140
DOI:10.1083/jcb.201106023

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