E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells
Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metasta...
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| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
The journal of cell biology
Year: 2011, Volume: 195, Issue: 5, Pages: 873-887 |
| ISSN: | 1540-8140 |
| DOI: | 10.1083/jcb.201106023 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1083/jcb.201106023
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| Author Notes: | Beate K. Straub, Steffen Rickelt, Ralf Zimbelmann, Christine Grund, Caecilia Kuhn, Marcus Iken, Michael Ott, Peter Schirmacher, and Werner W. Franke |
MARC
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| 520 | |a Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this “cadherin switch” hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered. | ||
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