Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency
Purpose: The aim of this study was to determine the value of systemic biochemical markers of bone turnover—urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)—in the diagnosis of chondral de...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 January 2011
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| In: |
International orthopaedics
Year: 2011, Volume: 35, Issue: 11, Pages: 1633-1637 |
| ISSN: | 1432-5195 |
| DOI: | 10.1007/s00264-010-1191-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00264-010-1191-5
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| Author Notes: | Nikolaus A. Streich, David Zimmermann, Holger Schmitt, Gerrit Bode |
| Summary: | Purpose: The aim of this study was to determine the value of systemic biochemical markers of bone turnover—urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)—in the diagnosis of chondral defects after anterior cruciate ligament (ACL) rupture. Thirty-eight patients with previous ACL rupture were included. Methods: Magnetic resonance imaging (MRI) of the injured and the intact knee joint was performed with volumetric measurement of volume and area of cartilage (VC/AC), area of subchondral bone (cAB), and area of subchondral bone denuded and eroded (dAB). Biochemical markers were measured using commercially available enzyme-linked immunoassays. Results: MRI-based volumetric cartilage measurement showed significant differences between the injured and the intact knees. uCTX-I, sCOMP and in parts uCTX-II correlated well with MRI parameters. CTX-I showed a significant correlation with VC and AC of the whole knee joint. Conclusions: The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee. |
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| Item Description: | Gesehen am 24.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1432-5195 |
| DOI: | 10.1007/s00264-010-1191-5 |