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Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency

Purpose: The aim of this study was to determine the value of systemic biochemical markers of bone turnover—urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)—in the diagnosis of chondral de...

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Hauptverfasser: Streich, Nikolaus (VerfasserIn) , Zimmermann, David (VerfasserIn) , Schmitt, Holger (VerfasserIn) , Bode, Gerrit (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 11 January 2011
In: International orthopaedics
Year: 2011, Jahrgang: 35, Heft: 11, Pages: 1633-1637
ISSN:1432-5195
DOI:10.1007/s00264-010-1191-5
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00264-010-1191-5
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Verfasserangaben:Nikolaus A. Streich, David Zimmermann, Holger Schmitt, Gerrit Bode
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Zusammenfassung:Purpose: The aim of this study was to determine the value of systemic biochemical markers of bone turnover—urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)—in the diagnosis of chondral defects after anterior cruciate ligament (ACL) rupture. Thirty-eight patients with previous ACL rupture were included. Methods: Magnetic resonance imaging (MRI) of the injured and the intact knee joint was performed with volumetric measurement of volume and area of cartilage (VC/AC), area of subchondral bone (cAB), and area of subchondral bone denuded and eroded (dAB). Biochemical markers were measured using commercially available enzyme-linked immunoassays. Results: MRI-based volumetric cartilage measurement showed significant differences between the injured and the intact knees. uCTX-I, sCOMP and in parts uCTX-II correlated well with MRI parameters. CTX-I showed a significant correlation with VC and AC of the whole knee joint. Conclusions: The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee.
Beschreibung:Gesehen am 24.10.2022
Beschreibung:Online Resource
ISSN:1432-5195
DOI:10.1007/s00264-010-1191-5

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