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Measuring forces between two single actin filaments during bundle formation

Bundles of filamentous actin are dominant cytoskeletal structures, which play a crucial role in various cellular processes. As yet quantifying the fundamental interaction between two individual actin filaments forming the smallest possible bundle has not been realized. Applying holographic optical t...

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Bibliographic Details
Main Authors: Streichfuss, Martin (Author) , Erbs, Friedrich Philipp Joachim Erich (Author) , Uhrig, Kai (Author) , Kurre, Rainer (Author) , Clemen, Anabel E.-M. (Author) , Böhm, Christian H. J. (Author) , Haraszti, Tamás (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: 12 August 2011
In: Nano letters
Year: 2011, Volume: 11, Issue: 9, Pages: 3676-3680
ISSN:1530-6992
DOI:10.1021/nl201630y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl201630y
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Author Notes:Martin Streichfuss, Friedrich Erbs, Kai Uhrig, Rainer Kurre, Anabel E.-M. Clemen, Christian H.J. Böhm, Tamás Haraszti, and Joachim P. Spatz
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Summary:Bundles of filamentous actin are dominant cytoskeletal structures, which play a crucial role in various cellular processes. As yet quantifying the fundamental interaction between two individual actin filaments forming the smallest possible bundle has not been realized. Applying holographic optical tweezers integrated with a microfluidic platform, we were able to measure the forces between two actin filaments during bundle formation. Quantitative analysis yields forces up to 0.2 pN depending on the concentration of bundling agents.
Item Description:Gesehen am 24.10.2022
Physical Description:Online Resource
ISSN:1530-6992
DOI:10.1021/nl201630y

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