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Measuring forces between two single actin filaments during bundle formation

Bundles of filamentous actin are dominant cytoskeletal structures, which play a crucial role in various cellular processes. As yet quantifying the fundamental interaction between two individual actin filaments forming the smallest possible bundle has not been realized. Applying holographic optical t...

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Hauptverfasser: Streichfuss, Martin (VerfasserIn) , Erbs, Friedrich Philipp Joachim Erich (VerfasserIn) , Uhrig, Kai (VerfasserIn) , Kurre, Rainer (VerfasserIn) , Clemen, Anabel E.-M. (VerfasserIn) , Böhm, Christian H. J. (VerfasserIn) , Haraszti, Tamás (VerfasserIn) , Spatz, Joachim P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 12 August 2011
In: Nano letters
Year: 2011, Jahrgang: 11, Heft: 9, Pages: 3676-3680
ISSN:1530-6992
DOI:10.1021/nl201630y
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl201630y
Volltext
Verfasserangaben:Martin Streichfuss, Friedrich Erbs, Kai Uhrig, Rainer Kurre, Anabel E.-M. Clemen, Christian H.J. Böhm, Tamás Haraszti, and Joachim P. Spatz
Beschreibung
Zusammenfassung:Bundles of filamentous actin are dominant cytoskeletal structures, which play a crucial role in various cellular processes. As yet quantifying the fundamental interaction between two individual actin filaments forming the smallest possible bundle has not been realized. Applying holographic optical tweezers integrated with a microfluidic platform, we were able to measure the forces between two actin filaments during bundle formation. Quantitative analysis yields forces up to 0.2 pN depending on the concentration of bundling agents.
Beschreibung:Gesehen am 24.10.2022
Beschreibung:Online Resource
ISSN:1530-6992
DOI:10.1021/nl201630y

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