Inverse electron-demand Diels-Alder reactions for the selective and efficient labeling of RNA
We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does no...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[2011]
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| In: |
Chemical communications
Year: 2011, Volume: 47, Issue: 46, Pages: 12536-12537 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C1CC15476A |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C1CC15476A Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2011/cc/c1cc15476a 
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| Author Notes: | Juliane Schoch, Sandeep Ameta, Andres Jäschke |
| Summary: | We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does not require transition metals. |
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| Item Description: | Gesehen am 25.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C1CC15476A |