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A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis

According to the current consensus, murine neural stem cells (NSCs) apically contacting the lateral ventricle generate differentiated progenitors by rare asymmetric divisions or by relocating to the basal side of the ventricular–subventricular zone (V-SVZ). Both processes will ultimately lead to the...

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Main Authors: Baur, Katja (Author) , Abdullah, Yomn (Author) , Mandl, Claudia (Author) , Hölzl-Wenig, Gabriele (Author) , Shi, Yan (Author) , Edelkraut, Udo (Author) , Khatri, Priti (Author) , Hagenston, Anna M (Author) , Irmler, Martin (Author) , Beckers, Johannes (Author) , Ciccolini, Francesca (Author)
Format: Article (Journal)
Language:English
Published: 21 July 2022
In: EMBO reports
Year: 2022, Volume: 23, Issue: 9, Pages: 1-20
ISSN:1469-3178
DOI:10.15252/embr.202154078
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.15252/embr.202154078
Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/embr.202154078
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Author Notes:Katja Baur, Yomn Abdullah, Claudia Mandl, Gabriele Hölzl-Wenig, Yan Shi, Udo Edelkraut, Priti Khatri, Anna M Hagenston, Martin Irmler, Johannes Beckers & Francesca Ciccolini
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Summary:According to the current consensus, murine neural stem cells (NSCs) apically contacting the lateral ventricle generate differentiated progenitors by rare asymmetric divisions or by relocating to the basal side of the ventricular–subventricular zone (V-SVZ). Both processes will ultimately lead to the generation of adult-born olfactory bulb (OB) interneurons. In contrast to this view, we here find that adult-born OB interneurons largely derive from an additional NSC-type resident in the basal V-SVZ.
Item Description:Gesehen am 26.10.2022
Physical Description:Online Resource
ISSN:1469-3178
DOI:10.15252/embr.202154078

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