The interleukin-6 promoter -597/-572/-174 genotype does not affect interleukin-6 production in hemodialysis patients
Kidney transplant recipients with the interleukin-6 (IL-6) GGG/GGG promoter −597/−572/−174genotype were shown to have a better long-term outcome. Further, the same −597/−572/−174genotype was found to be associated with less IL-6 production in healthy control subjects. To verify this observation in p...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 Aug 2011
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| In: |
Journal of interferon & cytokine research
Year: 2011, Volume: 31, Issue: 8, Pages: 639-642 |
| ISSN: | 1557-7465 |
| DOI: | 10.1089/jir.2010.0141 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/jir.2010.0141 Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/jir.2010.0141 
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| Author Notes: | Friederike Schulte, Peter Schnülle, Peter Bugert, Harald Klüter, and Michael Müller-Steinhardt |
| Summary: | Kidney transplant recipients with the interleukin-6 (IL-6) GGG/GGG promoter −597/−572/−174genotype were shown to have a better long-term outcome. Further, the same −597/−572/−174genotype was found to be associated with less IL-6 production in healthy control subjects. To verify this observation in potential kidney transplant recipients, IL-6 production was analyzed in 85/142 hemodialysis patients. We could not confirm an impaired IL-6 secretion in carriers of the GGG/GGG −597/−572/−174genotype and propose a significantly lower IL-6 production in hemodialysis patients versus healthy control subjects to explain this. However, we suggest subsequent studies of IL-6 production in kidney allograft recipients to further elucidate the pathophysiological relevance of IL-6 for transplant outcome. |
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| Item Description: | Die Ziffern -597/-572/-174 sind im Titel hochgestellt Gesehen am 27.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1557-7465 |
| DOI: | 10.1089/jir.2010.0141 |