The interleukin-6 promoter -597/-572/-174 genotype does not affect interleukin-6 production in hemodialysis patients

Kidney transplant recipients with the interleukin-6 (IL-6) GGG/GGG promoter −597/−572/−174genotype were shown to have a better long-term outcome. Further, the same −597/−572/−174genotype was found to be associated with less IL-6 production in healthy control subjects. To verify this observation in p...

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Hauptverfasser: Schulte, Friederike Barbara (VerfasserIn) , Schnülle, Peter (VerfasserIn) , Bugert, Peter (VerfasserIn) , Klüter, Harald (VerfasserIn) , Müller-Steinhardt, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 Aug 2011
In: Journal of interferon & cytokine research
Year: 2011, Jahrgang: 31, Heft: 8, Pages: 639-642
ISSN:1557-7465
DOI:10.1089/jir.2010.0141
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/jir.2010.0141
Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/jir.2010.0141
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Verfasserangaben:Friederike Schulte, Peter Schnülle, Peter Bugert, Harald Klüter, and Michael Müller-Steinhardt

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520 |a Kidney transplant recipients with the interleukin-6 (IL-6) GGG/GGG promoter −597/−572/−174genotype were shown to have a better long-term outcome. Further, the same −597/−572/−174genotype was found to be associated with less IL-6 production in healthy control subjects. To verify this observation in potential kidney transplant recipients, IL-6 production was analyzed in 85/142 hemodialysis patients. We could not confirm an impaired IL-6 secretion in carriers of the GGG/GGG −597/−572/−174genotype and propose a significantly lower IL-6 production in hemodialysis patients versus healthy control subjects to explain this. However, we suggest subsequent studies of IL-6 production in kidney allograft recipients to further elucidate the pathophysiological relevance of IL-6 for transplant outcome. 
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