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Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain

The glutamatergic theory of schizophrenia proposes a dysfunction of ionotropic N-methyl-d-aspartate receptors (NMDA-R). Several therapeutic strategies address NMDA-R function and the effects of antipsychotic agents on NMDA-R expression have been described. Within the second-generation antipsychotics...

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Bibliographic Details
Main Authors: Segnitz, Nina (Author) , Ferbert, Thomas (Author) , Schmitt, Andrea (Author) , Gass, Peter (Author) , Gebicke-Härter, Peter J. (Author) , Zink, Mathias (Author)
Format: Article (Journal)
Language:English
Published: 12 April 2011
In: Psychopharmacology
Year: 2011, Volume: 217, Pages: 127-142
ISSN:1432-2072
DOI:10.1007/s00213-011-2262-z
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00213-011-2262-z
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Author Notes:Nina Segnitz, Thomas Ferbert, Andrea Schmitt, Peter Gass, Peter J. Gebicke-Haerter, Mathias Zink
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Summary:The glutamatergic theory of schizophrenia proposes a dysfunction of ionotropic N-methyl-d-aspartate receptors (NMDA-R). Several therapeutic strategies address NMDA-R function and the effects of antipsychotic agents on NMDA-R expression have been described. Within the second-generation antipsychotics, the partial dopaminergic and serotonergic agonist aripiprazole (APZ) was able to counteract the behavioral effects of NMDA-R antagonists.
Item Description:Gesehen am 31.10.2022
Physical Description:Online Resource
ISSN:1432-2072
DOI:10.1007/s00213-011-2262-z

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