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IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-RCT2 will foc...

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Main Authors: Leone, Caterina (Author) , Di Stefano, Giulia (Author) , Di Pietro, Giuseppe (Author) , Bloms-Funke, Petra (Author) , Boesl, Irmgard (Author) , Caspani, Ombretta (Author) , Chapman, Sonya C. (Author) , Finnerup, Nanna Brix (Author) , Garcia-Larrea, Luis (Author) , Li, Tom (Author) , Goetz, Marcus (Author) , Mouraux, André (Author) , Pelz, Bernhard (Author) , Pogatzki-Zahn, Esther M. (Author) , Schilder, Andreas (Author) , Schnetter, Erik (Author) , Schubart, Karin (Author) , Tracey, Irene (Author) , Troconiz, Inaki F. (Author) , Van Niel, Hans (Author) , Hernandez, Jose Miguel Vela (Author) , Vincent, Katy (Author) , Vollert, Jan (Author) , Wanigasekera, Vishvarani (Author) , Wittayer, Matthias Sebastian (Author) , Phillips, Keith G. (Author) , Truini, Andrea (Author) , Treede, Rolf-Detlef (Author)
Format: Article (Journal)
Language:English
Published: 05 September 2022
In: Trials
Year: 2022, Volume: 23, Pages: 1-26
ISSN:1468-6694
DOI:10.1186/s13063-022-06431-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13063-022-06431-5
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Author Notes:Caterina Leone, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Nanna Brix Finnerup, Luis Garcia-Larrea, Tom Li, Marcus Goetz, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart, Irene Tracey, Inaki F. Troconiz, Hans Van Niel, Jose Miguel Vela Hernandez, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer, Keith G. Phillips, Andrea Truini, Rolf-Detlef Treede
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Summary:IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-RCT2 will focus on human spinal cord and brainstem activity using biomarkers derived from non-invasive neurophysiological measurements.
Item Description:Gesehen am 31.10.2022
Physical Description:Online Resource
ISSN:1468-6694
DOI:10.1186/s13063-022-06431-5

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