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Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

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The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared regi...

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Bibliographic Details
Main Authors: Vrančić, Christian (Author) , Fomichova, Anna (Author) , Gretz, Norbert (Author) , Herrmann, Carina (Author) , Neudecker, Sabine (Author) , Pucci, Annemarie (Author) , Petrich, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 27 January 2011
In: The analyst
Year: 2011, Volume: 136, Issue: 6, Pages: 1192-1198
ISSN:1364-5528
DOI:10.1039/C0AN00537A
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C0AN00537A
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2011/an/c0an00537a
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Author Notes:Christian Vrančić, Anna Fomichova, Norbert Gretz, Carina Herrmann, Sabine Neudecker, Annemarie Pucci and Wolfgang Petrich
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Summary:The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed.
Item Description:Gesehen am 03.11.2022
Physical Description:Online Resource
ISSN:1364-5528
DOI:10.1039/C0AN00537A

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