Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro
The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared regi...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 January 2011
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| In: |
The analyst
Year: 2011, Jahrgang: 136, Heft: 6, Pages: 1192-1198 |
| ISSN: | 1364-5528 |
| DOI: | 10.1039/C0AN00537A |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C0AN00537A Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2011/an/c0an00537a 
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| Verfasserangaben: | Christian Vrančić, Anna Fomichova, Norbert Gretz, Carina Herrmann, Sabine Neudecker, Annemarie Pucci and Wolfgang Petrich |
| Zusammenfassung: | The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed. |
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| Beschreibung: | Gesehen am 03.11.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1364-5528 |
| DOI: | 10.1039/C0AN00537A |