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Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer

The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation. The aim of this ph...

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Detalles Bibliográficos
Autores principales: Timke, Carmen (Autor) , Schmitz-Winnenthal, Friedrich Hubertus (Autor) , Klug, Felix (Autor) , Röder, Falk (Autor) , Bonertz, Andreas (Autor) , Reißfelder, Christoph (Autor) , Rochet, Nathalie (Autor) , Koch, Moritz (Autor) , Tjaden, Christin (Autor) , Büchler, Markus W. (Autor) , Debus, Jürgen (Autor) , Werner, Jens (Autor) , Beckhove, Philipp (Autor) , Weitz, Jürgen (Autor) , Huber, Peter E. (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 13 April 2011
In: BMC cancer
Year: 2011, Volumen: 11, Pages: 1-7
ISSN:1471-2407
DOI:10.1186/1471-2407-11-134
Acceso en línea:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-11-134
Enlace del recurso
Notas de Autor:Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz and Peter E Huber
Descripción
Sumario:The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation. The aim of this phase I/II clinical trial is to evaluate whether low dose single fraction radiotherapy can improve T cell associated antitumor immune response in patients with pancreatic cancer.
Notas:Gesehen am 03.11.2022
Descripción Física:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-11-134

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