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Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis

Abstract: Recently, it was discovered that the receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) is part of an important signal transduction pathway for tissue homoeostasis. Therefore, we were interested in investigating RANKL expression in the epidermis of skin lesions from patient...

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Main Authors: Toberer, Ferdinand (Author) , Sykora, Jaromir (Author) , Göttel, Daniel (Author) , Ruland, Vincent (Author) , Hartschuh, Wolfgang (Author) , Enk, Alexander (Author) , Luger, Thomas A. (Author) , Beissert, Stefan (Author) , Loser, Karin (Author) , Joos, Stefan (Author) , Krammer, Peter H. (Author) , Kuhn, Annegret (Author)
Format: Article (Journal) Editorial
Language:English
Published: 22 June 2011
In: Experimental dermatology
Year: 2011, Volume: 20, Issue: 7, Pages: 600-602
ISSN:1600-0625
DOI:10.1111/j.1600-0625.2011.01303.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0625.2011.01303.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0625.2011.01303.x
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Author Notes:Ferdinand Toberer, Jaromir Sykora, Daniel Göttel, Vincent Ruland, Wolfgang Hartschuh, Alexander Enk, Thomas A. Luger, Stefan Beissert, Karin Loser, Stefan Joos, Peter H. Krammer and Annegret Kuhn
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Summary:Abstract: Recently, it was discovered that the receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) is part of an important signal transduction pathway for tissue homoeostasis. Therefore, we were interested in investigating RANKL expression in the epidermis of skin lesions from patients with different subtypes of cutaneous lupus erythematosus (CLE) and psoriasis as well as normal healthy donors. Using the tissue microarray technique, skin biopsy specimens were evaluated by immunohistochemistry. RANKL showed a significantly increased expression in the epidermis of skin biopsy specimens from patients with psoriasis (median: 4, range: 0-5) compared to patients with CLE (median: 0, range: 0-4) (P < 0.001). No significant differences in epidermal RANKL expression between the CLE subtypes were detected. These data show a different expression of RANKL in the epidermis of skin lesions from patients with CLE compared to those with psoriasis suggesting that RANKL might play an important role in the pathogenesis of the disease.
Item Description:Letter to the editor
Gesehen am 10.11.2022
Physical Description:Online Resource
ISSN:1600-0625
DOI:10.1111/j.1600-0625.2011.01303.x

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