Cover Image

Progestin treatment for the prevention of preterm birth

Progestin supplementation appears to be a promising approach to both preventing initiation of preterm labor and treating it once it is already established, given the role of progesterone in maintaining pregnancy, as well as support from basic and clinical research. Progesterone and 17α-hydroxyproges...

Full description

Saved in:
Bibliographic Details
Main Authors: Lucovnik, Miha (Author) , Kuon, Ruben-Jeremias (Author) , Chambliss, Linda R. (Author) , Maner, William L. (Author) , Shi, Shao-Qing (Author) , Shi, Leili (Author) , Balducci, James (Author) , Garfield, Robert E. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Acta obstetricia et gynecologica Scandinavica
Year: 2011, Volume: 90, Issue: 10, Pages: 1057-1069
ISSN:1600-0412
DOI:10.1111/j.1600-0412.2011.01178.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0412.2011.01178.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0412.2011.01178.x
Get full text
Author Notes:Miha Lucovnik, Ruben J. Kuon, Linda R. Chambliss, William L. Maner, Shao-Qing Shi, Leili Shi, James Balducci & Robert E. Garfield
Description
Summary:Progestin supplementation appears to be a promising approach to both preventing initiation of preterm labor and treating it once it is already established, given the role of progesterone in maintaining pregnancy, as well as support from basic and clinical research. Progesterone and 17α-hydroxyprogesterone acetate slow the process of cervical ripening, and this is the rationale for prophylactic long-term progestin supplementation mostly studied so far. However, progesterone (but not 17α-hydroxyprogesterone acetate) also inhibits myometrial activity even after the cervix has already ripened. Moreover, these effects depend greatly on the vehicle used and the route of administration. Understanding different mechanisms of action, as well as the importance of progestin formulation, vehicle and route of administration, is the key to finding the optimal progestin treatment for prevention of preterm birth.
Item Description:Gesehen am 11.11.2022
Physical Description:Online Resource
ISSN:1600-0412
DOI:10.1111/j.1600-0412.2011.01178.x

Similar Items