Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often recurs after transplantation, and ~40 years ago, an unknown soluble factor in the recipient was hypothesized to exist to explain such cases....

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Main Authors: Wei, Changli (Author) , El Hindi, Shafic (Author) , Li, Jing (Author) , Fornoni, Alessia (Author) , Goes, Nelson (Author) , Sageshima, Junichiro (Author) , Maiguel, Dony (Author) , Karumanchi, S. Ananth (Author) , Yap, Hui-Kim (Author) , Saleem, Moin (Author) , Zhang, Qingyin (Author) , Nikolic, Boris (Author) , Chaudhuri, Abanti (Author) , Daftarian, Pirouz (Author) , Salido, Eduardo (Author) , Torres, Armando (Author) , Salifu, Moro (Author) , Sarwal, Minnie M. (Author) , Schaefer, Franz (Author) , Morath, Christian (Author) , Schwenger, Vedat (Author) , Zeier, Martin (Author) , Gupta, Vineet (Author) , Roth, David (Author) , Rastaldi, Maria Pia (Author) , Burke, George (Author) , Ruiz, Phillip (Author) , Reiser, Jochen (Author)
Format: Article (Journal)
Language:English
Published: 31 July 2011
In: Nature medicine
Year: 2011, Volume: 17, Issue: 8, Pages: 952-960
ISSN:1546-170X
DOI:10.1038/nm.2411
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.2411
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.2411
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Author Notes:Changli Wei, Shafic El Hindi, Jing Li, Alessia Fornoni, Nelson Goes, Junichiro Sageshima, Dony Maiguel, S. Ananth Karumanchi, Hui-Kim Yap, Moin Saleem, Qingyin Zhang, Boris Nikolic, Abanti Chaudhuri, Pirouz Daftarian, Eduardo Salido, Armando Torres, Moro Salifu, Minnie M. Sarwal, Franz Schaefer, Christian Morath, Vedat Schwenger, Martin Zeier, Vineet Gupta, David Roth, Maria Pia Rastaldi, George Burke, Phillip Ruiz & Jochen Reiser
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Summary:Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often recurs after transplantation, and ~40 years ago, an unknown soluble factor in the recipient was hypothesized to exist to explain such cases. Jochen Reiser and his colleagues use data from human and mouse studies to show that soluble uPAR may be the long-sought-after soluble factor.
Item Description:Gesehen am 14.11.2022
Physical Description:Online Resource
ISSN:1546-170X
DOI:10.1038/nm.2411