Effects of chronic kidney disease on nanomechanics of the endothelial glycocalyx are mediated by the mineralocorticoid receptor

Endothelial mechanics control vascular reactivity and are regulated by the mineralocorticoid receptor (MR) and its downstream target, the epithelial Na+ channel (ENaC). Endothelial dysfunction is a hallmark of chronic kidney disease (CKD), but its mechanisms are poorly understood. We hypothesized th...

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Main Authors:	Fels, Benedikt (Author) , Beyer, Arne (Author) , Cazaña-Pérez, Violeta (Author) , Giraldez, Teresa (Author) , Navarro-González, Juan F. (Author) , Alvarez de la Rosa, Diego (Author) , Schaefer, Franz (Author) , Bayazit, Aysun K. (Author) , Obrycki, Łukasz (Author) , Ranchin, Bruno (Author) , Holle, Johannes (Author) , Querfeld, Uwe (Author) , Kusche-Vihrog, Kristina (Author)
Format:	Article (Journal)
Language:	English
Published:	13 September 2022
In:	International journal of molecular sciences Year: 2022, Volume: 23, Issue: 18, Pages: 1-14
ISSN:	1422-0067
DOI:	10.3390/ijms231810659
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms231810659 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/18/10659
Author Notes:	Benedikt Fels, Arne Beyer, Violeta Cazaña-Pérez, Teresa Giraldez, Juan F. Navarro-González, Diego Alvarez de la Rosa, Franz Schaefer, Aysun K. Bayazit, Łukasz Obrycki, Bruno Ranchin, Johannes Holle, Uwe Querfeld and Kristina Kusche-Vihrog