Selinexor in advanced, metastatic dedifferentiated liposarcoma: a multinational, randomized, double-blind, placebo-controlled trial

Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.

Bibliographic Details

Main Authors:	Gounder, Mrinal M. (Author) , Razak, Albiruni Abdul (Author) , Somaiah, Neeta (Author) , Chawla, Sant (Author) , Martin-Broto, Javier (Author) , Grignani, Giovanni (Author) , Schuetze, Scott M. (Author) , Vincenzi, Bruno (Author) , Wagner, Andrew J. (Author) , Chmielowski, Bartosz (Author) , Jones, Robin L. (Author) , Riedel, Richard F. (Author) , Stacchiotti, Silvia (Author) , Loggers, Elizabeth T. (Author) , Ganjoo, Kristen N. (Author) , Le Cesne, Axel (Author) , Italiano, Antoine (Author) , Garcia del Muro, Xavier (Author) , Burgess, Melissa (Author) , Piperno-Neumann, Sophie (Author) , Ryan, Christopher (Author) , Mulcahy, Mary F. (Author) , Forscher, Charles (Author) , Penel, Nicolas (Author) , Okuno, Scott (Author) , Elias, Anthony (Author) , Hartner, Lee (Author) , Philip, Tony (Author) , Alcindor, Thierry (Author) , Kasper, Bernd (Author) , Reichardt, Peter (Author) , Lapeire, Lore (Author) , Blay, Jean-Yves (Author) , Chevreau, Christine (Author) , Valverde Morales, Claudia Maria (Author) , Schwartz, Gary K. (Author) , Chen, James L. (Author) , Deshpande, Hari (Author) , Davis, Elizabeth J. (Author) , Nicholas, Garth (Author) , Gröschel, Stefan (Author) , Hatcher, Helen (Author) , Duffaud, Florence (Author) , Herráez, Antonio Casado (Author) , Beveridge, Roberto Diaz (Author) , Badalamenti, Giuseppe (Author) , Eriksson, Mikael (Author) , Meyer, Christian (Author) , von Mehren, Margaret (Author) , Van Tine, Brian A. (Author) , Götze, Katharina (Author) , Mazzeo, Filomena (Author) , Yakobson, Alexander (Author) , Zick, Aviad (Author) , Lee, Alexander (Author) , Gonzalez, Anna Estival (Author) , Napolitano, Andrea (Author) , Dickson, Mark A. (Author) , Michel, Dayana (Author) , Meng, Changting (Author) , Li, Lingling (Author) , Liu, Jianjun (Author) , Ben-Shahar, Osnat (Author) , Van Domelen, Dane R. (Author) , Walker, Christopher J. (Author) , Chang, Hua (Author) , Landesman, Yosef (Author) , Shah, Jatin J. (Author) , Shacham, Sharon (Author) , Kauffman, Michael G. (Author) , Attia, Steven (Author)
Format:	Article (Journal)
Language:	English
Published:	April 8, 2022
In:	Journal of clinical oncology Year: 2022, Volume: 40, Issue: 22, Pages: 2479-2490
ISSN:	1527-7755
DOI:	10.1200/JCO.21.01829
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1200/JCO.21.01829 Verlag, lizenzpflichtig, Volltext: https://ascopubs.org/doi/10.1200/JCO.21.01829
Author Notes:	Mrinal M. Gounder, Albiruni Abdul Razak, Neeta Somaiah, Sant Chawla, Javier Martin-Broto, Giovanni Grignani, Scott M. Schuetze, Bruno Vincenzi, Andrew J. Wagner, Bartosz Chmielowski, Robin L. Jones, Richard F. Riedel, Silvia Stacchiotti, Elizabeth T. Loggers, Kristen N. Ganjoo, Axel Le Cesne, Antoine Italiano, Xavier Garcia del Muro, Melissa Burgess, Sophie Piperno-Neumann, Christopher Ryan, Mary F. Mulcahy, Charles Forscher, Nicolas Penel, Scott Okuno, Anthony Elias, Lee Hartner, Tony Philip, Thierry Alcindor, Bernd Kasper, Peter Reichardt, Lore Lapeire, Jean-Yves Blay, Christine Chevreau, Claudia Maria Valverde Morales, Gary K. Schwartz, James L. Chen, Hari Deshpande, Elizabeth J. Davis, Garth Nicholas, Stefan Gröschel, Helen Hatcher, Florence Duffaud, Antonio Casado Herráez, Roberto Diaz Beveridge, Giuseppe Badalamenti, Mikael Eriksson, Christian Meyer, Margaret von Mehren, Brian A. Van Tine, Katharina Götze, Filomena Mazzeo, Alexander Yakobson, Aviad Zick, Alexander Lee, Anna Estival Gonzalez, Andrea Napolitano, Mark A. Dickson, Dayana Michel, Changting Meng, Lingling Li, Jianjun Liu, Osnat Ben-Shahar, Dane R. Van Domelen, Christopher J. Walker, Hua Chang, Yosef Landesman, Jatin J. Shah, Sharon Shacham, Michael G. Kauffman, and Steven Attia