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Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain novel 1,2,5-trisubstituted benzimidazole derivativ...

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Main Authors: Abdelhafiz, Abeer (Author) , Serya, Rabah A. T. (Author) , Lasheen, Deena S. (Author) , Wang, Nessa (Author) , Sobeh, Mansour (Author) , Wink, Michael (Author) , Abouzid, Khaled A. M. (Author)
Format: Article (Journal)
Language:English
Published: 27 Sep 2022
In: Journal of enzyme inhibition and medicinal chemistry
Year: 2022, Volume: 37, Issue: 1, Pages: 2710-2724
ISSN:1475-6374
DOI:10.1080/14756366.2022.2127700
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1080/14756366.2022.2127700
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2127700
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Author Notes:Abeer H.A. Abdelhafiz, Rabah A.T. Serya, Deena S. Lasheen, Nessa Wang, Mansour Sobeh, Michael Wink & Khaled A. M. Abouzid
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Summary:Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain novel 1,2,5-trisubstituted benzimidazole derivatives were designed utilising ligand based pharmacophore approach.
Item Description:Gesehen am 15.11.2022
Physical Description:Online Resource
ISSN:1475-6374
DOI:10.1080/14756366.2022.2127700

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