Determinants of current hand eczema: results from case-control studies nested in the PACO follow-up study (PACO II)
Background: Hand eczema is often a result of the interplay of exogenous and endogenous risk factors. Epidemiological studies demonstrating the interrelationship between these factors are lacking. Objective: To analyse risk factors associated with current hand eczema and current irritant hand eczema...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 May 2010
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| In: |
Contact dermatitis
Year: 2010, Volume: 62, Issue: 6, Pages: 363-370 |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/j.1600-0536.2010.01729.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0536.2010.01729.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0536.2010.01729.x 
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| Author Notes: | Christian J. Apfelbacher, Ulrich Funke, Magda Radulescu and Thomas L. Diepgen |
| Summary: | Background: Hand eczema is often a result of the interplay of exogenous and endogenous risk factors. Epidemiological studies demonstrating the interrelationship between these factors are lacking. Objective: To analyse risk factors associated with current hand eczema and current irritant hand eczema in two case-control studies nested in a long-term follow-up study in the car industry. Patients/Materials/Methods: Eligible participants were individuals who had been followed until the end of their apprenticeship in the original cohort study (1990-1998, N = 1909). Participants were interviewed and underwent dermatological examination. Two case-control studies were nested within the cohort, one using current hand eczema cases (n = 110) and one using current irritant hand eczema cases (n = 57). Multivariable modelling was performed. Results: The only significant finding was a positive association of atopic skin diathesis with hand eczema in both studies. Wet work ≥2 hr/day was positively related to current irritant hand eczema. Age and having an office job were inversely related to hand eczema. Conclusions: Atopic skin diathesis was the most important determinant of hand eczema. Constitution seems to play a dominant role compared with environmental and occupational hazards in a setting where skin protection measures are well established. |
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| Item Description: | Gesehen am 24.11.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/j.1600-0536.2010.01729.x |