Difficulties of interpreting Borrelia Serology in patients with Uveitis
Purpose: We aimed to review all uveitis patients with a positive Borrelia serology to evaluate positve results in uveitis subtypes. Further we wanted to test a self-assembled Interferon gamma release assay (IGRA) as a possible supplement method in these patients.Methods: Patients where serology for...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Ocular immunology and inflammation
Year: 2011, Volume: 19, Issue: 4, Pages: 227-231 |
| ISSN: | 1744-5078 |
| DOI: | 10.3109/09273948.2011.568662 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/09273948.2011.568662 Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.3109/09273948.2011.568662 
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| Author Notes: | Friederike Mackensen, Stefan Zimmermann, Werner Alle, Regina Max, Eva Jakob, Matthias D. Becker and Dorothea Thiemeyer |
| Summary: | Purpose: We aimed to review all uveitis patients with a positive Borrelia serology to evaluate positve results in uveitis subtypes. Further we wanted to test a self-assembled Interferon gamma release assay (IGRA) as a possible supplement method in these patients.Methods: Patients where serology for Borrelia was ordered from September 2005 to May 2008, were identified by database search. Patients with positive results in ELISA and Western Blot were retested by a self-assembled IGRA. Bayes Theorem was applied.Results: Testing for Borrelia was ordered for 184 patients. 18 patients (9,8%) showed positive results. 11 were positive for IgG (5,9 %), 3 were positive for IgG and IgM (1,6 %) and 4 for IgM (2,1%). Applying Bayes Theorem, we calculated a posttest-probability of 9% in case of a positive test result. 16 of the 18 patients were retested by IGRA. None of them showed a positive result.Conclusions: A positive serology with uveitis as the only clinical symptom is not sufficient to confirm Borreliosis as 5,9 % of patients with uveitis and a positive IgG serology correspond to the normal spread of Borrelia in the population. Looking at posttest-probability shows a lot of false-positive test results when testing all uveitis patients for Borrelia routinely. |
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| Item Description: | Gesehen am 24.11.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1744-5078 |
| DOI: | 10.3109/09273948.2011.568662 |