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Modulation of intestinal corticotropin-releasing hormone signaling by the herbal preparation STW 5-II: possible mechanisms for irritable bowel syndrome management

Corticotropin-releasing factor (CRF) mediates stress responses and alters the gut-brain axis, contributing to the pathogenesis of irritable bowel syndrome (IBS), which is recognized by abdominal pain accompanied by bowel habit disturbance. STW 5-II, a mixture of six herbal extracts, is clinically ef...

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Bibliographic Details
Main Authors: Elbadawi, Mohamed (Author) , Ammar, Ramy M. (Author) , Rabini, Sabine (Author) , Klauck, Sabine (Author) , Efferth, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 8 September 2022
In: Pharmaceuticals
Year: 2022, Volume: 15, Issue: 9, Pages: 1-17
ISSN:1424-8247
DOI:10.3390/ph15091121
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ph15091121
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1424-8247/15/9/1121
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Author Notes:Mohamed Elbadawi, Ramy M. Ammar, Sabine Rabini, Sabine M. Klauck and Thomas Efferth
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Summary:Corticotropin-releasing factor (CRF) mediates stress responses and alters the gut-brain axis, contributing to the pathogenesis of irritable bowel syndrome (IBS), which is recognized by abdominal pain accompanied by bowel habit disturbance. STW 5-II, a mixture of six herbal extracts, is clinically effective in functional dyspepsia and IBS. Here we aimed to establish an organoid-based stress-induced IBS-like model to investigate the mechanisms of action of STW 5-II.
Item Description:Gesehen am 29.11.2022
Physical Description:Online Resource
ISSN:1424-8247
DOI:10.3390/ph15091121

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