Riociguat in children with pulmonary arterial hypertension: the PATENT-CHILD study

Riociguat, a soluble guanylate cyclase stimulator, is approved for treatment of adults with pulmonary arterial hypertension (PAH). The safety, tolerability, and pharmacokinetics (PK) of oral riociguat in a pediatric population with PAH was assessed in PATENT-CHILD (NCT02562235), a multicenter, singl...

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Main Authors:	Garcia-Aguilar, Humberto (Author) , Gorenflo, Matthias (Author) , Ivy, D. Dunbar (Author) , Moledina, Shahin (Author) , Castaldi, Biagio (Author) , Ishida, Hidekazu (Author) , Cześniewicz, Paweł (Author) , Kusa, Jacek (Author) , Miera, Oliver (Author) , Pattathu, Joseph George (Author) , Weng, Ken-Pen (Author) , Ablonczy, Laszlo (Author) , Apitz, Christian (Author) , Katona, Marta (Author) , Kurosaki, Kenichi (Author) , Pulido, Tomas (Author) , Yamagishi, Hiroyuki (Author) , Yasuda, Kazushi (Author) , Cisternas, Galia (Author) , Goth, Melanie (Author) , Lippert, Susanne (Author) , Radomskyj, Anna (Author) , Saleh, Soundos (Author) , Willmann, Stefan (Author) , Wirsching, Gabriela (Author) , Bonnet, Damien (Author) , Beghetti, Maurice (Author)
Format:	Article (Journal)
Language:	English
Published:	01 September 2022
In:	Pulmonary circulation Year: 2022, Volume: 12, Issue: 3, Pages: 1-12
ISSN:	2045-8940
DOI:	10.1002/pul2.12133
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/pul2.12133 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/pul2.12133
Author Notes:	Humberto García Aguilar, Matthias Gorenflo, D. Dunbar Ivy, Shahin Moledina, Biagio Castaldi, Hidekazu Ishida, Paweł Cześniewicz, Jacek Kusa, Oliver Miera, Joseph Pattathu, Ken-Pen Weng, Laszlo Ablonczy, Christian Apitz, Marta Katona, Kenichi Kurosaki, Tomas Pulido, Hiroyuki Yamagishi, Kazushi Yasuda, Galia Cisternas, Melanie Goth, Susanne Lippert, Anna Radomskyj, Soundos Saleh, Stefan Willmann, Gabriela Wirsching, Damien Bonnet, Maurice Beghetti