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Chemical composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells

Background: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum o...

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Bibliographic Details
Main Authors: Sertel, Serkan (Author) , Eichhorn, Tolga (Author) , Plinkert, Peter K. (Author) , Efferth, Thomas (Author)
Format: Article (Journal)
Language:English
Published: [January 2011]
In: Anticancer research
Year: 2011, Volume: 31, Issue: 1, Pages: 185-191
ISSN:1791-7530
Online Access:Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/31/1/185
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Author Notes:Serkan Sertel, Tolga Eichhorn, Peter K. Plinkert and Thomas Efferth
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Summary:Background: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC). Materials and Methods: Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses. Results: Lovage essential oil extract had an IC50 value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling. Conclusion: Levisticum officinale essential oil inhibits human HNSCC cell growth.
Item Description:Gesehen am 30.11.2022
Physical Description:Online Resource
ISSN:1791-7530

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