The evolving plasticity of coagulation protease-dependent cytoprotective signalling = Neue Erkenntnisse über die Plastizität der Gerinnungsproteasen-vermittelten Zytoprotektion
Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particu...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
{2011]
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| In: |
Hämostaseologie
Year: 2011, Volume: 31, Issue: 03, Pages: 179-184 |
| ISSN: | 2567-5761 |
| DOI: | 10.5482/ha-1162 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.5482/ha-1162 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.5482/ha-1162 
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| Author Notes: | K. Shahzad, B. Isermann |
| Summary: | Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article. |
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| Item Description: | Gesehen am 30.11.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2567-5761 |
| DOI: | 10.5482/ha-1162 |