Buchumschlag

The evolving plasticity of coagulation protease-dependent cytoprotective signalling = Neue Erkenntnisse über die Plastizität der Gerinnungsproteasen-vermittelten Zytoprotektion

Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Shahzad Hussain, Khurrum (VerfasserIn) , Isermann, Berend (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: {2011]
In: Hämostaseologie
Year: 2011, Jahrgang: 31, Heft: 03, Pages: 179-184
ISSN:2567-5761
DOI:10.5482/ha-1162
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.5482/ha-1162
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.5482/ha-1162
Volltext
Verfasserangaben:K. Shahzad, B. Isermann
Beschreibung
Zusammenfassung:Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article.
Beschreibung:Gesehen am 30.11.2022
Beschreibung:Online Resource
ISSN:2567-5761
DOI:10.5482/ha-1162

Ähnliche Einträge