Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia
Sharma A, Weisbrod M, Kaiser S, Markela-Lerenc J, Bender S. Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia. Objective: Fronto-posterior networks have been implicated in various cognitive processes that are impaired in schizophrenia. This is the fi...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[February 2011]
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| In: |
Acta psychiatrica Scandinavica
Year: 2011, Volume: 123, Issue: 2, Pages: 125-135 |
| ISSN: | 1600-0447 |
| DOI: | 10.1111/j.1600-0447.2010.01603.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0447.2010.01603.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0447.2010.01603.x 
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| Author Notes: | A. Sharma, M. Weisbrod, S. Kaiser, J. Markela-Lerenc, S. Bender |
| Summary: | Sharma A, Weisbrod M, Kaiser S, Markela-Lerenc J, Bender S. Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia. Objective: Fronto-posterior networks have been implicated in various cognitive processes that are impaired in schizophrenia. This is the first study on time and frequency resolved fronto-posterior coherence during cognitive control in schizophrenia. Method: We examined 16 schizophrenic/schizoaffective patients and 20 age-matched controls performing a choice-reaction task. Fronto-posterior coherence was analyzed for event-related increases with respect to the inter-trial interval. Furthermore, we compared the two groups for event-related coherence during the task-related time intervals which showed a significant coherence increase with respect to the inter-trial interval, as well as for absolute coherence during the inter-trial interval. Results: Event-related coherence was significantly reduced in patients during time intervals (0-250 ms poststimulus) when controls showed significant event-related coherence increases. However, patients showed significantly higher absolute coherence during the inter-trial interval. These results pointed to differential deficits in fronto-posterior connectivity during the inter-trial interval and task-related conditions in schizophrenia. Conclusion: Cognitive deficits in schizophrenia might be driven by abnormal fronto-posterior communication. Task-related hypo-connectivity and inter-trial interval hyper-connectivity point to resource allocation deficits. The timing of cortico-cortical interactions during crucial task-related intervals may be impaired, while frontal and posterior areas may exhibit increased interactions between the trials. |
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| Item Description: | First published: 16 September 2010 Gesehen am 30.11.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0447 |
| DOI: | 10.1111/j.1600-0447.2010.01603.x |