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Mismatch repair deficiency, chemotherapy and survival for resectable gastric cancer: an observational study from the German staR cohort and a meta-analysis$doriginal article : clinical oncology

In a post hoc analysis of the MAGIC trial, patients with curatively resected gastric cancer (GC) and mismatch repair (MMR) deficiency (MMRd) had better median overall survival (OS) when treated with surgery alone but worse median OS when treated with additional chemotherapy. Further data are require...

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Main Authors: Stolze, Thilo (Author) , Franke, Sabine (Author) , Haybäck, Johannes (Author) , Möhler, Markus (Author) , Grimminger, Peter (Author) , Lang, Hauke (Author) , Roth, Wilfried (Author) , Gockel, Ines (Author) , Kreuser, Nicole (Author) , Bläker, Hendrik (Author) , Wittekind, Christian (Author) , Lordick, Florian (Author) , Vieth, Michael (Author) , Veits, Lothar (Author) , Waidmann, Oliver (Author) , Lingohr, Philipp (Author) , Peitz, Ulrich (Author) , Schildberg, Claus (Author) , Kruschewski, Martin (Author) , Vassos, Nikolaos (Author) , Goni, Elisabetta (Author) , Bruns, Christiane (Author) , Ridwelski, Karsten (Author) , Wolff, Stefanie (Author) , Lippert, Hans (Author) , Schumacher, Johannes (Author) , Malfertheiner, Peter (Author) , Venerito, Marino (Author)
Format: Article (Journal)
Language:English
Published: March 2023
In: Journal of cancer research and clinical oncology
Year: 2023, Volume: 149, Issue: 3, Pages: 1007-1017
ISSN:1432-1335
DOI:10.1007/s00432-022-03953-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00432-022-03953-y
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00432-022-03953-y
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Author Notes:T. Stolze, S. Franke, J. Haybaeck, M. Moehler, P.P. Grimminger, H. Lang, W. Roth, I. Gockel, N. Kreuser, H. Bläker, C. Wittekind, F. Lordick, M. Vieth, L. Veits, O. Waidmann, P. Lingohr, U. Peitz, C. Schildberg, M. Kruschewski, N. Vassos, E. Goni, C.J. Bruns, K. Ridwelski, S. Wolff, H. Lippert, J. Schumacher, P. Malfertheiner, M. Venerito
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Summary:In a post hoc analysis of the MAGIC trial, patients with curatively resected gastric cancer (GC) and mismatch repair (MMR) deficiency (MMRd) had better median overall survival (OS) when treated with surgery alone but worse median OS when treated with additional chemotherapy. Further data are required to corroborate these findings.
Item Description:Online veröffentlicht: 25. Februar 2022
Gesehen am 29.07.2024
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-022-03953-y

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