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Evidence for correlations between BMI-associated SNPs and circRNAs

Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. An...

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Main Authors: Rajcsanyi, Luisa Sophie (Author) , Diebels, Inga (Author) , Pastoors, Lydia (Author) , Kanber, Deniz (Author) , Peters, Triinu (Author) , Volckmar, Anna-Lena (Author) , Zheng, Yiran (Author) , Grosse, Martin (Author) , Dieterich, Christoph (Author) , Hebebrand, Johannes (Author) , Kaiser, Frank (Author) , Horsthemke, Bernhard (Author) , Hinney, Anke (Author)
Format: Article (Journal)
Language:English
Published: 25 July 2022
In: Scientific reports
Year: 2022, Volume: 12, Pages: 1-13
ISSN:2045-2322
DOI:10.1038/s41598-022-16495-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-022-16495-7
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-022-16495-7
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Author Notes:Luisa Sophie Rajcsanyi, Inga Diebels, Lydia Pastoors, Deniz Kanber, Triinu Peters, Anna-Lena Volckmar, Yiran Zheng, Martin Grosse, Christoph Dieterich, Johannes Hebebrand, Frank J. Kaiser, Bernhard Horsthemke & Anke Hinney
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Summary:Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. Analysis of sex-stratified GWAS data revealed that circRNA genomic loci encompassed more genome-wide significant BMI-SNPs in females than in males. To explore whether the enrichment is restricted to BMI, we investigated nine additional GWAS studies. We showed an enrichment of trait-associated SNPs in circRNAs for four analysed phenotypes (body height, chronic kidney disease, anorexia nervosa and autism spectrum disorder). To analyse the influence of BMI-affecting SNPs on circRNA levels in vitro, we examined rs4752856 located on hsa_circ_0022025. The analysis of heterozygous individuals revealed an increased level of circRNA derived from the BMI-increasing SNP allele. We conclude that genetic variation may affect the BMI partly through circRNAs.
Item Description:Gesehen am 05.12.2022
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-022-16495-7

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