Real-world efficacy and safety of mobocertinib in EGFR exon 20 insertion-mutated lung cancer
Non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertions (EGFRex20ins) is relatively resistant to the existing EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is a novel TKI that selectively targets EGFRex20ins and has demonstrated therapeutic efficacy in pretreated patients with tu...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 September 2022
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| In: |
Frontiers in oncology
Year: 2022, Jahrgang: 12, Pages: 1-9 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2022.1010311 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2022.1010311 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2022.1010311 |
| Verfasserangaben: | Waleed Kian, Petros Christopoulos, Areen A. Remilah, Esther Levison, Elizabeth Dudnik, Walid Shalata, Bilal Krayim, Ranin Marei, Alexander Yakobson, Martin Faehling, Dolev Kahala, Inbal Sara Granot, Dina Levitas, Nir Peled and Laila C. Roisman |
| Zusammenfassung: | Non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertions (EGFRex20ins) is relatively resistant to the existing EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is a novel TKI that selectively targets EGFRex20ins and has demonstrated therapeutic efficacy in pretreated patients with tumors harboring these mutations. |
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| Beschreibung: | Gesehen am 06.12.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2022.1010311 |