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The number of glomeruli and pyruvate metabolism is not strongly coupled in the healthy rat kidney

Purpose The number of glomeruli is different in men and women, as they also present different prevalence and progression of chronic kidney disease. A recent study has demonstrated a potential difference in renal metabolism between sexes, and a potential explanation could be the differences in glomer...

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Main Authors: Bech, Sabrina Kahina (Author) , Qi, Haiyun (Author) , Mariager, Christian Østergaard (Author) , Hansen, Esben Søvsø Szocska (Author) , Ilicak, Efe (Author) , Zöllner, Frank G. (Author) , Laustsen, Christoffer (Author)
Format: Article (Journal)
Language:English
Published: February 2022
In: Magnetic resonance in medicine
Year: 2022, Volume: 87, Issue: 2, Pages: 896-903
ISSN:1522-2594
DOI:10.1002/mrm.29025
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mrm.29025
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.29025
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Author Notes:Sabrina Kahina Bech, Haiyun Qi, Christian Østergaard Mariager, Esben Søvsø Szocska Hansen, Efe Ilicak, Frank G. Zöllner, Christoffer Laustsen
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Summary:Purpose The number of glomeruli is different in men and women, as they also present different prevalence and progression of chronic kidney disease. A recent study has demonstrated a potential difference in renal metabolism between sexes, and a potential explanation could be the differences in glomeruli number. This study investigates the potential correlation between glomerular number and pyruvate metabolism in healthy kidneys. Methods This study is an experimental study with rats (N = 12). We used cationized-ferritin MRI to visualize and count glomeruli and hyperpolarized [1-13C]pyruvate to map the metabolism. Dynamic contrast-enhanced MRI was used to analyze kidney hemodynamics using gadolinium tracer. Results Data showed no or subtle correlation between the number of glomeruli and the pyruvate metabolism. Minor differences were observed in the number of glomeruli (female = 24,509 vs. male = 26 350; p = .16), renal plasma flow (female = 606.6 vs. male= 455.7 ml/min/100 g; p = .18), and volume of distribution (female = 87.44 vs. male = 76.61 ml/100 ml; p = .54) between sexes. Mean transit time was significantly prolonged in males compared with females (female = 8.868 s vs. male = 10.63 s; p = .04). Conclusion No strong statistically significant correlation between the number of glomeruli and the pyruvate metabolism was found in healthy rat kidneys.
Item Description:Onine veröffentlicht am 23. September 2021
Gesehen am 06.12.2022
Physical Description:Online Resource
ISSN:1522-2594
DOI:10.1002/mrm.29025

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