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FLASH with carbon ions: tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence...

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Main Authors: Tinganelli, Walter (Author) , Weber, Uli (Author) , Puspitasari, Anggraeini (Author) , Simoniello, Palma (Author) , Abdollahi, Amir (Author) , Oppermann, Julius (Author) , Schuy, Christoph (Author) , Horst, Felix (Author) , Helm, Alexander (Author) , Fournier, Claudia (Author) , Durante, Marco (Author)
Format: Article (Journal)
Language:English
Published: 7 May 2022
In: Radiotherapy and oncology
Year: 2022, Volume: 175, Pages: 185-190
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.003
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.05.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022002389
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Author Notes:Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante
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Summary:The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence with heavy ions is limited to in vitro cell experiments. Here we present the first in vivo results with high-energy 12C-ions delivered at an ultra-high dose rate.
Item Description:Gesehen am 06.12.2022
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.003

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