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FLASH with carbon ions: tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence...

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Hauptverfasser: Tinganelli, Walter (VerfasserIn) , Weber, Uli (VerfasserIn) , Puspitasari, Anggraeini (VerfasserIn) , Simoniello, Palma (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Oppermann, Julius (VerfasserIn) , Schuy, Christoph (VerfasserIn) , Horst, Felix (VerfasserIn) , Helm, Alexander (VerfasserIn) , Fournier, Claudia (VerfasserIn) , Durante, Marco (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 7 May 2022
In: Radiotherapy and oncology
Year: 2022, Jahrgang: 175, Pages: 185-190
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.003
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.05.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022002389
Volltext
Verfasserangaben:Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante
Beschreibung
Zusammenfassung:The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence with heavy ions is limited to in vitro cell experiments. Here we present the first in vivo results with high-energy 12C-ions delivered at an ultra-high dose rate.
Beschreibung:Gesehen am 06.12.2022
Beschreibung:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.003

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