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Changes in radical levels as a cause for the FLASH effect: impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O2 content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanism...

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Main Authors: Jansen, Jeannette (Author) , Beyreuther, Elke (Author) , Garcia-Calderón, Daniel (Author) , Karsch, Leonhard (Author) , Knoll, Jan (Author) , Pawelke, Jörg (Author) , Schürer, Michael (Author) , Seco, Joao (Author)
Format: Article (Journal)
Language:English
Published: 27 August 2022
In: Radiotherapy and oncology
Year: 2022, Volume: 175, Pages: 193-196
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.08.024
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.08.024
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022042451
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Author Notes:Jeannette Jansen, Elke Beyreuther, Daniel García-Calderón, Leonhard Karsch, Jan Knoll, Jörg Pawelke, Michael Schürer, Joao Seco
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Summary:The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O2 content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.
Item Description:Gesehen am 06.12.2022
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.08.024

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