Technology development to evaluate the effectiveness of viscosity reducing excipients
Addition of pharmaceutical excipients is a commonly used approach to decrease the viscosity of highly concentrated protein formulations, which otherwise could not be subcutaneously injected or processed. The variety of protein-protein interactions, which are responsible for increased viscosities, ma...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 September 2022
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| In: |
International journal of pharmaceutics
Year: 2022, Volume: 626, Pages: 1-9 |
| ISSN: | 1873-3476 |
| DOI: | 10.1016/j.ijpharm.2022.122204 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijpharm.2022.122204 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S037851732200758X 
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| Author Notes: | Niels Banik, Stefan Braun, Jan Gerit Brandenburg, Gert Fricker, Devendra S. Kalonia, Tobias Rosenkranz |
| Summary: | Addition of pharmaceutical excipients is a commonly used approach to decrease the viscosity of highly concentrated protein formulations, which otherwise could not be subcutaneously injected or processed. The variety of protein-protein interactions, which are responsible for increased viscosities, makes a portfolio approach necessary. Screening of several excipients to develop such a portfolio is time and money consuming in industrial settings. Responsible protein-protein interactions were investigated using the interaction parameter kD obtained from dynamic light scattering measurements in the studies presented herein. Together with in-silico calculated excipient parameter, kD could be used as a screening tool accelerating screening and formulation development as kD is suitable to high-throughput formats using small quantities of protein and low concentrations. A qualitative correlation between kD and high-concentration viscosity behavior could be shown in our case. |
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| Item Description: | Gesehen am 07.12.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3476 |
| DOI: | 10.1016/j.ijpharm.2022.122204 |