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Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study

Despite recent advances in the management of septic shock, mortality rates are still unacceptably high. Early identification of the high-mortality risk group for early intervention remains an issue under exploration. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth fact...

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Bibliographic Details
Main Authors: Yang, Kuang-Yao (Author) , Liu, Kuan-Ting (Author) , Chen, Yu-Chun (Author) , Chen, Chun-Sheng (Author) , Lee, Yu-Chin (Author) , Perng, Reury-Perng (Author) , Feng, Jia-Yih (Author)
Format: Article (Journal)
Language:English
Published: 10 January 2011
In: Critical care
Year: 2011, Volume: 15, Pages: 1-11
ISSN:1466-609X
DOI:10.1186/cc9412
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/cc9412
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Author Notes:Kuang-Yao Yang, Kuan-Ting Liu, Yu-Chun Chen, Chun-Sheng Chen, Yu-Chin Lee, Reury-Perng Perng, Jia-Yih Feng
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Summary:Despite recent advances in the management of septic shock, mortality rates are still unacceptably high. Early identification of the high-mortality risk group for early intervention remains an issue under exploration. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-1 (sVEGFR1) and urokinase plasminogen activator (uPA) have diverse effects in the pathogenesis of sepsis, which involve pro-inflammation, anti-inflammation, endothelial cell repair, and vascular permeability change. Their roles in predicting mortality and organ dysfunction remain to be clarified.
Item Description:Gesehen am 12.12.2022
Physical Description:Online Resource
ISSN:1466-609X
DOI:10.1186/cc9412

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