Serum and gene expression profile of cytokines following combination of yoga training and vitamin D supplementation in breast cancer survivors: a randomized controlled trial
Background: This study aimed to examine the effect of the combination of yoga training with high vitamin D dose supplementation on the expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods: Thirty volunteered breast cancer survivors (4...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 March 2022
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| In: |
BMC women's health
Year: 2022, Volume: 22, Pages: 1-11 |
| ISSN: | 1472-6874 |
| DOI: | 10.1186/s12905-022-01671-8 |
| Online Access: | kostenfrei kostenfrei 
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| Author Notes: | Mahdi Naderi, Hajar Kordestani, Zahra Sahebi, Vahid Khedmati Zare, Sadegh Amani-Shalamzari, Mojtaba Kaviani, Joachim Wiskemann and Mahdieh Molanouri Shamsi |
| Summary: | Background: This study aimed to examine the effect of the combination of yoga training with high vitamin D dose supplementation on the expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods: Thirty volunteered breast cancer survivors (48 +/- 8 years) were randomly allocated to a high dose (4000 IU) of vitamin D supplementation (HD) group (n = 10), yoga with a high dose of vitamin D (YHD) group (n = 10), and yoga with a low dose (2000 IU) of vitamin D (YLD) group (n = 10). Participants performed the Hatha yoga style for 12 weeks, twice a week. Blood samples, quality of life (QoL) questionnaire, and physical performance tests were taken before and after the intervention. Results: Body fat percentage (eta p(2) = 0.36), handgrip strength (eta p(2) = 0.41) and QoL indicators include global health (eta p(2) = 0.54), functional scales (eta p(2) = 0.49), and symptoms scales (eta p(2) = 0.50) were significantly improved in the both YHD and YLD groups compared to the HD group (p < 0.05). Also, interleukin-10 (IL-10) levels were markedly increased in the Y-HVD group compared to the Y-LVD and HVD groups. Moreover, there were significant decreases in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 levels in the Y-HVD group after the intervention. The anti-inflammatory index (IL-10/TNF-alpha) was significantly increased in both the yoga groups (P < 0.05). Conclusion: Yoga promotes physical and psychological fitness and, in combination with a high dose of vitamin D, improves the cytokine profile, which can effectively manage the side effects associated with cancer. |
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| Item Description: | Gesehen am 13.12.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1472-6874 |
| DOI: | 10.1186/s12905-022-01671-8 |